Skip to content
EACON 2020

EurAsian Conference on Nanophotonics

April 6 – 9, 2020 / Jena, Germany


Ondrej Stranik

Department of Microscopy, Leibniz Institute of Photonic Technology, Jena, Germany

Label-free sensing for biomedical diagnostics

A fast and cost-efficient identification of a variety of pathogens in different matrices represents a major challenge in medical diagnostics, pharmacy or food industry. The pathogens are usually identified by some kind of specific bio-markers such as proteins or DNA strands. In the current praxis these bio-markers has to be labelled (fluorescent tags, enzymatic tags), which requires several sample preparation steps. In our approach, we focus on label-free detection based on spectroscopy of optical nanoresonators, where the specific adsorption of the bio-markers on the resonator is associated with the shift of its resonance frequency. Excellent representatives of the optical resonators appropriate for the task are metallic nanostructures. Their plasmon resonance is in the visible light and their dimensions are close the size of the bio-markers. In the talk, all necessary steps to construct such plasmonic biosensors will be discusses. First, our strategies to fabricate the plasmonic nanostructures will be presented.1,2 Afterwards, the development of the optical instrumentation for the detection on single nanostructure or on an ensemble of nanostructures will be shown.3,4 And finally, alternative sensing principle with plasmonic structure will be discussed.5

Figure 1. Schematic illustration of different steps in the development of plasmonic sensors.

1 A. Pittner, S. Wendt, D. Zopf, A. Dathe, N. Grosse, A. Csáki, W. Fritzsche and O. Stranik, Anal. Bioanal. Chem., 2019, 411, 1537–1547.
2 M. Thiele, J. Z. E. Soh, A. Knauer, D. Malsch, O. Stranik, R. Müller, A. Csáki, T. Henkel, J. M. Köhler and W. Fritzsche, Chem. Eng. J., 2016, 288, 432–440.
3 D. Zopf, J. Jatschka, A. Dathe, N. Jahr, W. Fritzsche and O. Stranik, Biosens. Bioelectron., 2016, 81, 287–293.
4 D. Zopf, A. Pittner, A. Dathe, N. Grosse, A. Csáki, K. Arstila, J. J. Toppari, W. Schott, D. Dontsov, G. Uhlrich, W. Fritzsche and O. Stranik, ACS Sens., 2019, 4, 335–343.
5 A. Dathe, M. Ziegler, U. Hübner, W. Fritzsche and O. Stranik, Nano Lett., 2016, 16, 5728–5736.

Further Talks

Andrea Csáki

Microfludic Synthesis of plasmonic Nanoparticles for Sensing Applications

Andrey Turchanin

Controlled growth of transition metal dichalcogenide monolayers for applications in nanoelectronic and nanophotonic devices

Chi Chen

Near Field Spectroscopic Imaging: from Hard to Soft Materials

Chi-How Peng

Cobalt mediated controlled/living radical polymerization: from mechanism understanding to materials application

Chun-Hong Kuo

Bridging Energy and Chemistry via Nanoarchitectonic Engineering at Atomic Scale

Falk Eilenberger

Integration of two-dimensional materials in optical systems for nonlinear optics, sensing, and single photon sources

Frank Setzpfandt

Nonlinear frequency conversion in nanostructured optical systems for application in quantum photonics

Heng-Liang Wu

Controlling the Oxidation State of Cu Electrode and Reaction Intermediates for Electrochemical CO2 Reduction to Ethylene

Kien-Voon Kong

Direct Observation of Reaction Intermediates of Metal-based Therapeutic Agents in Single Living Cell Using TERS

Maria Wächtler

Quantum confined semiconductor nanostructures in light-driven catalysis

Martin Presselt

Supramolecular Control of Optical and Electronical Properties of Two-Dimensional Dye Layers

Po-Chiao Lin

New Environment Sensitive Fluorophores with Color-Tailored Emission: In Vivo Monitoring of Carbonic Anhydrases Expression on Growth of Larval Zebrafish

Shangjr (Felix) Gwo

Plasmonic Metasurface-Enhanced Linear and Nonlinear Processes in Two-Dimensional Semiconductors

Ta-Jen Yen

Empowering Bilayer MoS2 by Engineered Plasmonic Nanostructures for Optoelectronic Applications

Tiow-Gan Ong

Carbodicarbene, Carbogenic Maverick, Not a Moderate!

Volker Deckert

Plasmon Enhanced Probe Spectroscopies – Structural Investigation of Nanoscale Objects

Yi-Tsu Chan

Molecular self-assembly methodology for rational construction of metallosupramolecules with high structural complexity

Yian Tai

Toward a universal polymeric material for electrode buffer layers in organic optoelectronics

Yu-Jung Lu

Controlling Light-matter Interactions at Nanoscale with Plasmonics: From Spontaneous Emission to Lasing